circuitpython/ports/stm32/boards/PYBV10/deploy.md

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Pyboard v1.x via DFU

One you have downloaded the appropriate DFU file it can be flashed directly to your pyboard using a DFU programmer. You can enter the DFU bootloader on the pyboard by executing machine.bootloader() at the MicroPython REPL.

Alternatively, connect 3V3 with BOOT0 and reset the board. For information about DFU programming on Windows see this PDF. For Linux and Mac see here.