diff --git a/ports/stm32/boards/NUCLEO_WL55/board.json b/ports/stm32/boards/NUCLEO_WL55/board.json
new file mode 100644
index 0000000000..d756a4cdbb
--- /dev/null
+++ b/ports/stm32/boards/NUCLEO_WL55/board.json
@@ -0,0 +1,15 @@
+{
+    "deploy": [
+        "../deploy.md"
+    ],
+    "docs": "",
+    "features": [],
+    "images": [
+        "nucleo_wl55.jpg"
+    ],
+    "mcu": "stm32wl",
+    "product": "Nucleo WL55",
+    "thumbnail": "",
+    "url": "",
+    "vendor": "ST Microelectronics"
+}
diff --git a/ports/stm32/boards/NUCLEO_WL55/mpconfigboard.h b/ports/stm32/boards/NUCLEO_WL55/mpconfigboard.h
new file mode 100644
index 0000000000..baf1f023be
--- /dev/null
+++ b/ports/stm32/boards/NUCLEO_WL55/mpconfigboard.h
@@ -0,0 +1,63 @@
+/* This file is part of the MicroPython project, https://micropython.org/
+ * MIT License; Copyright (c) 2021 Damien P. George
+ */
+
+#define MICROPY_HW_BOARD_NAME                   "NUCLEO-WL55"
+#define MICROPY_HW_MCU_NAME                     "STM32WL55JCI7"
+
+#define MICROPY_EMIT_THUMB                      (0)
+#define MICROPY_EMIT_INLINE_THUMB               (0)
+#define MICROPY_PY_BUILTINS_COMPLEX             (0)
+#define MICROPY_PY_GENERATOR_PEND_THROW         (0)
+#define MICROPY_PY_MATH                         (0)
+#define MICROPY_PY_FRAMEBUF                     (0)
+#define MICROPY_PY_USOCKET                      (0)
+#define MICROPY_PY_NETWORK                      (0)
+#define MICROPY_PY_ONEWIRE                      (0)
+#define MICROPY_PY_STM                          (0)
+#define MICROPY_PY_PYB_LEGACY                   (0)
+#define MICROPY_PY_UHEAPQ                       (0)
+#define MICROPY_PY_UTIMEQ                       (0)
+
+#define MICROPY_HW_HAS_FLASH                    (1)
+#define MICROPY_HW_ENABLE_RTC                   (1)
+#define MICROPY_HW_ENABLE_RNG                   (1)
+#define MICROPY_HW_ENABLE_ADC                   (0) // use machine.ADC instead
+#define MICROPY_HW_HAS_SWITCH                   (1)
+
+// There is an external 32kHz oscillator
+#define MICROPY_HW_RTC_USE_LSE                  (1)
+#define MICROPY_HW_RTC_USE_US                   (1)
+
+// UART buses
+#define MICROPY_HW_UART1_TX                     (pin_B6)    // Arduino D1, pin 7 on CN9
+#define MICROPY_HW_UART1_RX                     (pin_B7)    // Arduino D0, pin 8 on CN9
+#define MICROPY_HW_LPUART1_TX                   (pin_A2)    // ST-link
+#define MICROPY_HW_LPUART1_RX                   (pin_A3)    // ST-link
+#define MICROPY_HW_UART_REPL                    PYB_LPUART_1
+#define MICROPY_HW_UART_REPL_BAUD               115200
+
+// I2C buses
+#define MICROPY_HW_I2C1_SCL                     (pin_A12)   // Arduino D15, pin 10 on CN5
+#define MICROPY_HW_I2C1_SDA                     (pin_A11)   // Arduino D14, pin 9 on CN5
+#define MICROPY_HW_I2C3_SCL                     (pin_B13)   // Arduino A5, pin 6 on CN8
+#define MICROPY_HW_I2C3_SDA                     (pin_B14)   // Arduino A4, pin 5 on CN8
+
+// SPI buses
+#define MICROPY_HW_SPI1_NSS                     (pin_A4)    // Arduino D10  pin 3 on CN5
+#define MICROPY_HW_SPI1_SCK                     (pin_A5)    // Arduino D13, pin 6 on CN5
+#define MICROPY_HW_SPI1_MISO                    (pin_A6)    // Arduino D12, pin 5 on CN5
+#define MICROPY_HW_SPI1_MOSI                    (pin_A7)    // Arduino D11, pin 4 on CN5
+
+// User switch; pressing the button makes the input go low
+#define MICROPY_HW_USRSW_PIN                    (pin_A0)
+#define MICROPY_HW_USRSW_PULL                   (GPIO_PULLUP)
+#define MICROPY_HW_USRSW_EXTI_MODE              (GPIO_MODE_IT_FALLING)
+#define MICROPY_HW_USRSW_PRESSED                (0)
+
+// LEDs
+#define MICROPY_HW_LED1                         (pin_B15) // blue
+#define MICROPY_HW_LED2                         (pin_B9) // green
+#define MICROPY_HW_LED3                         (pin_B11) // red
+#define MICROPY_HW_LED_ON(pin)                  (mp_hal_pin_high(pin))
+#define MICROPY_HW_LED_OFF(pin)                 (mp_hal_pin_low(pin))
diff --git a/ports/stm32/boards/NUCLEO_WL55/mpconfigboard.mk b/ports/stm32/boards/NUCLEO_WL55/mpconfigboard.mk
new file mode 100644
index 0000000000..210f3058c1
--- /dev/null
+++ b/ports/stm32/boards/NUCLEO_WL55/mpconfigboard.mk
@@ -0,0 +1,13 @@
+MCU_SERIES = wl
+CMSIS_MCU = STM32WL55xx
+AF_FILE = boards/stm32wl55_af.csv
+STARTUP_FILE = $(STM32LIB_CMSIS_BASE)/Source/Templates/gcc/startup_stm32wl55xx_cm4.o
+LD_FILES = boards/stm32wl55xc.ld boards/common_basic.ld
+TEXT0_ADDR = 0x08000000
+
+# MicroPython settings
+MICROPY_VFS_FAT = 0
+MICROPY_VFS_LFS2 = 1
+
+# Don't include default frozen modules because MCU is tight on flash space
+FROZEN_MANIFEST ?=
diff --git a/ports/stm32/boards/NUCLEO_WL55/pins.csv b/ports/stm32/boards/NUCLEO_WL55/pins.csv
new file mode 100644
index 0000000000..afcf34df11
--- /dev/null
+++ b/ports/stm32/boards/NUCLEO_WL55/pins.csv
@@ -0,0 +1,46 @@
+,PA0
+,PA1
+,PA2
+,PA3
+,PA4
+,PA5
+,PA6
+,PA7
+,PA8
+,PA9
+,PA10
+,PA11
+,PA12
+,PA13
+,PA14
+,PA15
+,PB0
+,PB1
+,PB2
+,PB3
+,PB4
+,PB5
+,PB6
+,PB7
+,PB8
+,PB9
+,PB10
+,PB11
+,PB12
+,PB13
+,PB14
+,PB15
+,PC0
+,PC1
+,PC2
+,PC3
+,PC4
+,PC5
+,PC6
+SW,PA0
+SW1,PA0
+SW2,PA1
+SW3,PC6
+LED_GREEN,PB9
+LED_RED,PB11
+LED_BLUE,PB15
diff --git a/ports/stm32/boards/NUCLEO_WL55/stm32wlxx_hal_conf.h b/ports/stm32/boards/NUCLEO_WL55/stm32wlxx_hal_conf.h
new file mode 100644
index 0000000000..2c28cc3d2a
--- /dev/null
+++ b/ports/stm32/boards/NUCLEO_WL55/stm32wlxx_hal_conf.h
@@ -0,0 +1,18 @@
+/* This file is part of the MicroPython project, https://micropython.org/
+ * The MIT License (MIT)
+ * Copyright (c) 2021 Damien P. George
+ */
+#ifndef MICROPY_INCLUDED_STM32WLXX_HAL_CONF_H
+#define MICROPY_INCLUDED_STM32WLXX_HAL_CONF_H
+
+// Oscillator values in Hz
+#define HSE_VALUE (32000000)
+#define LSE_VALUE (32768)
+
+// Oscillator timeouts in ms
+#define HSE_STARTUP_TIMEOUT (100)
+#define LSE_STARTUP_TIMEOUT (5000)
+
+#include "boards/stm32wlxx_hal_conf_base.h"
+
+#endif // MICROPY_INCLUDED_STM32WLXX_HAL_CONF_H