diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 67c93fc02b..ea2985e4f8 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -154,8 +154,24 @@ jobs:
       with:
         name: mpy-cross-macos-catalina
         path: mpy-cross/mpy-cross
+    - name: Select SDK for M1 build
+      run: sudo xcode-select -switch /Applications/Xcode_12.3.app
+    - name: Build mpy-cross (arm64)
+      run: make -C mpy-cross -j2 -f Makefile.m1 V=2
+    - uses: actions/upload-artifact@v2
+      with:
+        name: mpy-cross-macos-bigsur-arm64
+        path: mpy-cross/mpy-cross-arm64
+    - name: Make universal binary
+      run: lipo -create -output mpy-cross-macos-universal mpy-cross/mpy-cross mpy-cross/mpy-cross-arm64
+    - uses: actions/upload-artifact@v2
+      with:
+        name: mpy-cross-macos-universal
+        path: mpy-cross-macos-universal
     - name: Upload mpy-cross build to S3
       run: |
+        [ -z "$AWS_ACCESS_KEY_ID" ] || aws s3 cp mpy-cross-macos-universal s3://adafruit-circuit-python/bin/mpy-cross/mpy-cross-macos-universal-${{ env.CP_VERSION }} --no-progress --region us-east-1
+        [ -z "$AWS_ACCESS_KEY_ID" ] || aws s3 cp mpy-cross/mpy-cross-arm64 s3://adafruit-circuit-python/bin/mpy-cross/mpy-cross-macos-bigsur-${{ env.CP_VERSION }}-arm64 --no-progress --region us-east-1
         [ -z "$AWS_ACCESS_KEY_ID" ] || aws s3 cp mpy-cross/mpy-cross s3://adafruit-circuit-python/bin/mpy-cross/mpy-cross-macos-catalina-${{ env.CP_VERSION }} --no-progress --region us-east-1
       env:
         AWS_PAGER: ''
diff --git a/mpy-cross/Makefile.m1 b/mpy-cross/Makefile.m1
new file mode 100644
index 0000000000..063036f597
--- /dev/null
+++ b/mpy-cross/Makefile.m1
@@ -0,0 +1,11 @@
+# SPDX-FileCopyrightText: 2014 MicroPython & CircuitPython contributors (https://github.com/adafruit/circuitpython/graphs/contributors)
+#
+# SPDX-License-Identifier: MIT
+
+PROG=mpy-cross-arm64
+BUILD=build-arm64
+
+include mpy-cross.mk
+# Because mpy-cross.mk unconditionally overwrites CC for Darwin, we must set it BELOW the inclusion
+CC := $(shell xcrun --sdk macosx11.1 --find clang) -isysroot $(shell xcrun --sdk macosx11.1 --show-sdk-path) -target arm64-apple-macos11 -DMICROPY_NLR_SETJMP=1
+$(info pt2 CC=$(CC))