diff --git a/lib/tinyusb b/lib/tinyusb
index 1f95f439e1..c59fa77427 160000
--- a/lib/tinyusb
+++ b/lib/tinyusb
@@ -1 +1 @@
-Subproject commit 1f95f439e11f519e69d75a4a8b7b9f28eaf5060e
+Subproject commit c59fa774274b13790a3ae0fc19d9651eeba560ab
diff --git a/ports/atmel-samd/supervisor/usb.c b/ports/atmel-samd/supervisor/usb.c
index d13ca0ef13..b8a94790d7 100644
--- a/ports/atmel-samd/supervisor/usb.c
+++ b/ports/atmel-samd/supervisor/usb.c
@@ -28,6 +28,7 @@
 #include "hpl/pm/hpl_pm_base.h"
 #include "hpl/gclk/hpl_gclk_base.h"
 #include "hal_gpio.h"
+#include "lib/tinyusb/src/device/usbd.h"
 
 void init_usb_hardware(void) {
     #ifdef SAMD21
@@ -57,3 +58,27 @@ void init_usb_hardware(void) {
     gpio_set_pin_function(PIN_PA25, PINMUX_PA25H_USB_DP);
     #endif
 }
+
+#ifdef SAMD21
+void USB_Handler(void) {
+    tud_int_handler(0);
+}
+#endif
+
+#ifdef SAMD51
+void USB_0_Handler (void) {
+  tud_int_handler(0);
+}
+
+void USB_1_Handler (void) {
+  tud_int_handler(0);
+}
+
+void USB_2_Handler (void) {
+  tud_int_handler(0);
+}
+
+void USB_3_Handler (void) {
+  tud_int_handler(0);
+}
+#endif
diff --git a/ports/litex/mphalport.c b/ports/litex/mphalport.c
index 0b8f012985..689487791e 100644
--- a/ports/litex/mphalport.c
+++ b/ports/litex/mphalport.c
@@ -27,6 +27,7 @@
 
 #include <string.h>
 
+#include "lib/tinyusb/src/device/usbd.h"
 #include "py/mphal.h"
 #include "py/mpstate.h"
 #include "py/gc.h"
@@ -36,10 +37,6 @@
 
 #include "irq.h"
 
-#ifdef CFG_TUSB_MCU
-    void hal_dcd_isr(uint8_t rhport);
-#endif
-
 /*------------------------------------------------------------------*/
 /* delay
  *------------------------------------------------------------------*/
@@ -72,7 +69,7 @@ void isr(void) {
 
 #ifdef CFG_TUSB_MCU
     if (irqs & (1 << USB_INTERRUPT))
-        hal_dcd_isr(0);
+        tud_int_handler(0);
 #endif
     if (irqs & (1 << TIMER0_INTERRUPT))
         SysTick_Handler();
diff --git a/ports/mimxrt10xx/supervisor/usb.c b/ports/mimxrt10xx/supervisor/usb.c
index 051fcca9de..1bc7ea9b56 100644
--- a/ports/mimxrt10xx/supervisor/usb.c
+++ b/ports/mimxrt10xx/supervisor/usb.c
@@ -56,5 +56,5 @@ void init_usb_hardware(void) {
 }
 
 void USB_OTG1_IRQHandler(void) {
-    tud_isr(0);
+    tud_int_handler(0);
 }
diff --git a/ports/nrf/supervisor/usb.c b/ports/nrf/supervisor/usb.c
index bb9d78101c..11a5a1561f 100644
--- a/ports/nrf/supervisor/usb.c
+++ b/ports/nrf/supervisor/usb.c
@@ -30,6 +30,7 @@
 #include "supervisor/usb.h"
 #include "lib/utils/interrupt_char.h"
 #include "lib/mp-readline/readline.h"
+#include "lib/tinyusb/src/device/usbd.h"
 
 #ifdef SOFTDEVICE_PRESENT
 #include "nrf_sdm.h"
@@ -87,3 +88,7 @@ void init_usb_hardware(void) {
         }
     }
 }
+
+void USBD_IRQHandler(void) {
+  tud_int_handler(0);
+}
diff --git a/ports/stm/supervisor/usb.c b/ports/stm/supervisor/usb.c
index b66107b7ba..b2f3ad86bd 100644
--- a/ports/stm/supervisor/usb.c
+++ b/ports/stm/supervisor/usb.c
@@ -30,6 +30,7 @@
 #include "supervisor/usb.h"
 #include "lib/utils/interrupt_char.h"
 #include "lib/mp-readline/readline.h"
+#include "lib/tinyusb/src/device/usbd.h"
 
 #include "py/mpconfig.h"
 
@@ -63,13 +64,13 @@ STATIC void init_usb_vbus_sense(void) {
 }
 
 void init_usb_hardware(void) {
-    //TODO: if future chips overload this with options, move to peripherals management. 
+    //TODO: if future chips overload this with options, move to peripherals management.
 
     GPIO_InitTypeDef GPIO_InitStruct = {0};
     /**USB_OTG_FS GPIO Configuration
     PA10     ------> USB_OTG_FS_ID
     PA11     ------> USB_OTG_FS_DM
-    PA12     ------> USB_OTG_FS_DP 
+    PA12     ------> USB_OTG_FS_DP
     */
     __HAL_RCC_GPIOA_CLK_ENABLE();
 
@@ -129,3 +130,7 @@ void init_usb_hardware(void) {
 
     init_usb_vbus_sense();
 }
+
+void OTG_FS_IRQHandler(void) {
+  tud_int_handler(0);
+}
diff --git a/supervisor/shared/usb/usb_desc.c b/supervisor/shared/usb/usb_desc.c
index 9b333d6fea..080187ebc5 100644
--- a/supervisor/shared/usb/usb_desc.c
+++ b/supervisor/shared/usb/usb_desc.c
@@ -52,7 +52,7 @@ uint8_t const * tud_hid_descriptor_report_cb(void) {
 
 // Invoked when received GET STRING DESCRIPTOR request
 // Application return pointer to descriptor, whose contents must exist long enough for transfer to complete
-uint16_t const* tud_descriptor_string_cb(uint8_t index) {
+uint16_t const* tud_descriptor_string_cb(uint8_t index, uint16_t langid) {
     uint8_t const max_index = sizeof(string_desc_arr)/sizeof(string_desc_arr[0]);
     return (index < max_index) ? string_desc_arr[index] : NULL;
 }