diff --git a/ports/stm32/i2c.c b/ports/stm32/i2c.c
index 0b7105344c..c63fe21624 100644
--- a/ports/stm32/i2c.c
+++ b/ports/stm32/i2c.c
@@ -268,7 +268,12 @@ int i2c_write(i2c_t *i2c, const uint8_t *src, size_t len, size_t next_len) {
     return num_acks;
 }
 
-#elif defined(STM32F0) || defined(STM32F7)
+#elif defined(STM32F0) || defined(STM32F7) || defined(STM32H7)
+
+#if defined(STM32H7)
+#define APB1ENR            APB1LENR
+#define RCC_APB1ENR_I2C1EN RCC_APB1LENR_I2C1EN
+#endif
 
 STATIC uint16_t i2c_timeout_ms[MICROPY_HW_MAX_I2C];
 
@@ -468,7 +473,7 @@ int i2c_write(i2c_t *i2c, const uint8_t *src, size_t len, size_t next_len) {
 
 #endif
 
-#if defined(STM32F0) || defined(STM32F4) || defined(STM32F7)
+#if defined(STM32F0) || defined(STM32F4) || defined(STM32F7) || defined(STM32H7)
 
 int i2c_readfrom(i2c_t *i2c, uint16_t addr, uint8_t *dest, size_t len, bool stop) {
     int ret;
diff --git a/ports/stm32/machine_i2c.c b/ports/stm32/machine_i2c.c
index 41e65cf05c..0976c18c81 100644
--- a/ports/stm32/machine_i2c.c
+++ b/ports/stm32/machine_i2c.c
@@ -38,7 +38,7 @@
 
 #define I2C_POLL_DEFAULT_TIMEOUT_US (50000) // 50ms
 
-#if defined(STM32F0) || defined(STM32F4) || defined(STM32F7)
+#if defined(STM32F0) || defined(STM32F4) || defined(STM32F7) || defined(STM32H7)
 
 typedef struct _machine_hard_i2c_obj_t {
     mp_obj_base_t base;