diff --git a/ports/cxd56/common-hal/busio/UART.c b/ports/cxd56/common-hal/busio/UART.c
index 2389cbf960..6c59c8f283 100644
--- a/ports/cxd56/common-hal/busio/UART.c
+++ b/ports/cxd56/common-hal/busio/UART.c
@@ -32,7 +32,6 @@
 #include <sys/time.h>
 #include <sys/select.h>
 #include <sys/ioctl.h>
-#include <arch/chip/pin.h>
 #include <nuttx/serial/tioctl.h>
 #include <nuttx/fs/ioctl.h>
 
@@ -42,22 +41,23 @@
 
 #include "shared-bindings/busio/UART.h"
 
+typedef struct {
+    const char* devpath;
+    const mcu_pin_obj_t *tx;
+    const mcu_pin_obj_t *rx;
+    int fd;
+} busio_uart_dev_t;
+
+STATIC busio_uart_dev_t busio_uart_dev[] = {
+    {"/dev/ttyS2", &pin_UART2_TXD, &pin_UART2_RXD, -1},
+};
+
 void common_hal_busio_uart_construct(busio_uart_obj_t *self,
     const mcu_pin_obj_t *tx, const mcu_pin_obj_t *rx, uint32_t baudrate,
     uint8_t bits, uart_parity_t parity, uint8_t stop, mp_float_t timeout,
     uint16_t receiver_buffer_size) {
     struct termios tio;
 
-    self->uart_fd = open("/dev/ttyS2", O_RDWR);
-    if (self->uart_fd < 0) {
-        mp_raise_ValueError(translate("Could not initialize UART"));
-    }
-
-    ioctl(self->uart_fd, TCGETS, (long unsigned int)&tio);
-    tio.c_speed = baudrate;
-    ioctl(self->uart_fd, TCSETS, (long unsigned int)&tio);
-    ioctl(self->uart_fd, TCFLSH, (long unsigned int)NULL);
-
     if (bits != 8) {
         mp_raise_ValueError(translate("Could not initialize UART"));
     }
@@ -70,10 +70,32 @@ void common_hal_busio_uart_construct(busio_uart_obj_t *self,
         mp_raise_ValueError(translate("Could not initialize UART"));
     }
 
-    if (tx->number != PIN_UART2_TXD || rx->number != PIN_UART2_RXD) {
+    self->number = -1;
+
+    for (int i = 0; i < MP_ARRAY_SIZE(busio_uart_dev); i++) {
+        if (tx->number == busio_uart_dev[i].tx->number &&
+            rx->number == busio_uart_dev[i].rx->number) {
+            self->number = i;
+            break;
+        }
+    }
+
+    if (self->number < 0) {
         mp_raise_ValueError(translate("Invalid pins"));
     }
 
+    if (busio_uart_dev[self->number].fd < 0) {
+        busio_uart_dev[self->number].fd = open(busio_uart_dev[self->number].devpath, O_RDWR);
+        if (busio_uart_dev[self->number].fd < 0) {
+            mp_raise_ValueError(translate("Could not initialize UART"));
+        }
+    }
+
+    ioctl(busio_uart_dev[self->number].fd, TCGETS, (long unsigned int)&tio);
+    tio.c_speed = baudrate;
+    ioctl(busio_uart_dev[self->number].fd, TCSETS, (long unsigned int)&tio);
+    ioctl(busio_uart_dev[self->number].fd, TCFLSH, (long unsigned int)NULL);
+
     claim_pin(tx);
     claim_pin(rx);
 
@@ -88,15 +110,15 @@ void common_hal_busio_uart_deinit(busio_uart_obj_t *self) {
         return;
     }
 
-    close(self->uart_fd);
-    self->uart_fd = -1;
+    close(busio_uart_dev[self->number].fd);
+    busio_uart_dev[self->number].fd = -1;
 
     reset_pin_number(self->tx_pin->number);
     reset_pin_number(self->rx_pin->number);
 }
 
 bool common_hal_busio_uart_deinited(busio_uart_obj_t *self) {
-    return self->uart_fd < 0;
+    return busio_uart_dev[self->number].fd < 0;
 }
 
 size_t common_hal_busio_uart_read(busio_uart_obj_t *self, uint8_t *data, size_t len, int *errcode) {
@@ -110,15 +132,15 @@ size_t common_hal_busio_uart_read(busio_uart_obj_t *self, uint8_t *data, size_t
     }
 
     FD_ZERO(&rfds);
-    FD_SET(self->uart_fd, &rfds);
+    FD_SET(busio_uart_dev[self->number].fd, &rfds);
 
     tv.tv_sec = 0;
     tv.tv_usec = self->timeout * 1000;
 
-    retval = select(self->uart_fd + 1, &rfds, NULL, NULL, &tv);
+    retval = select(busio_uart_dev[self->number].fd + 1, &rfds, NULL, NULL, &tv);
 
     if (retval) {
-        bytes_read = read(self->uart_fd, data, len);
+        bytes_read = read(busio_uart_dev[self->number].fd, data, len);
     } else {
         *errcode = EAGAIN;
         return MP_STREAM_ERROR;
@@ -128,8 +150,7 @@ size_t common_hal_busio_uart_read(busio_uart_obj_t *self, uint8_t *data, size_t
 }
 
 size_t common_hal_busio_uart_write(busio_uart_obj_t *self, const uint8_t *data, size_t len, int *errcode) {
-    int bytes_written = write(self->uart_fd, data, len);
-
+    int bytes_written = write(busio_uart_dev[self->number].fd, data, len);
     if (bytes_written < 0) {
         *errcode = MP_EAGAIN;
         return MP_STREAM_ERROR;
@@ -145,16 +166,16 @@ uint32_t common_hal_busio_uart_get_baudrate(busio_uart_obj_t *self) {
 void common_hal_busio_uart_set_baudrate(busio_uart_obj_t *self, uint32_t baudrate) {
     struct termios tio;
 
-    ioctl(self->uart_fd, TCGETS, (long unsigned int)&tio);
+    ioctl(busio_uart_dev[self->number].fd, TCGETS, (long unsigned int)&tio);
     tio.c_speed = baudrate;
-    ioctl(self->uart_fd, TCSETS, (long unsigned int)&tio);
-    ioctl(self->uart_fd, TCFLSH, (long unsigned int)NULL);
+    ioctl(busio_uart_dev[self->number].fd, TCSETS, (long unsigned int)&tio);
+    ioctl(busio_uart_dev[self->number].fd, TCFLSH, (long unsigned int)NULL);
 }
 
 uint32_t common_hal_busio_uart_rx_characters_available(busio_uart_obj_t *self) {
     int count = 0;
 
-    ioctl(self->uart_fd, FIONREAD, (long unsigned int)&count);
+    ioctl(busio_uart_dev[self->number].fd, FIONREAD, (long unsigned int)&count);
 
     return count;
 }
@@ -163,6 +184,6 @@ void common_hal_busio_uart_clear_rx_buffer(busio_uart_obj_t *self) {
 }
 
 bool common_hal_busio_uart_ready_to_tx(busio_uart_obj_t *self) {
-    ioctl(self->uart_fd, TCFLSH, (long unsigned int)NULL);
+    ioctl(busio_uart_dev[self->number].fd, TCFLSH, (long unsigned int)NULL);
     return true;
 }
diff --git a/ports/cxd56/common-hal/busio/UART.h b/ports/cxd56/common-hal/busio/UART.h
index 1c01cfbb9a..c1f6fff533 100644
--- a/ports/cxd56/common-hal/busio/UART.h
+++ b/ports/cxd56/common-hal/busio/UART.h
@@ -33,7 +33,7 @@
 
 typedef struct {
     mp_obj_base_t base;
-    int uart_fd;
+    int8_t number;
     const mcu_pin_obj_t *tx_pin;
     const mcu_pin_obj_t *rx_pin;
     uint32_t baudrate;