diff --git a/ports/stm32/modmachine.c b/ports/stm32/modmachine.c
index 639ee9fad4..be36431cff 100644
--- a/ports/stm32/modmachine.c
+++ b/ports/stm32/modmachine.c
@@ -524,6 +524,20 @@ STATIC mp_obj_t machine_sleep(void) {
 
     // reconfigure the system clock after waking up
 
+    #if defined(STM32F0)
+
+    // Enable HSI48
+    __HAL_RCC_HSI48_ENABLE();
+    while (!__HAL_RCC_GET_FLAG(RCC_FLAG_HSI48RDY)) {
+    }
+
+    // Select HSI48 as system clock source
+    MODIFY_REG(RCC->CFGR, RCC_CFGR_SW, RCC_SYSCLKSOURCE_HSI48);
+    while (__HAL_RCC_GET_SYSCLK_SOURCE() != RCC_CFGR_SWS_HSI48) {
+    }
+
+    #else
+
     // enable HSE
     __HAL_RCC_HSE_CONFIG(MICROPY_HW_CLK_HSE_STATE);
     while (!__HAL_RCC_GET_FLAG(RCC_FLAG_HSERDY)) {
@@ -545,6 +559,8 @@ STATIC mp_obj_t machine_sleep(void) {
 
     #endif
 
+    #endif
+
     return mp_const_none;
 }
 MP_DEFINE_CONST_FUN_OBJ_0(machine_sleep_obj, machine_sleep);