diff --git a/lib/tinyusb b/lib/tinyusb
index 73896a3b71..ea8ecea59a 160000
--- a/lib/tinyusb
+++ b/lib/tinyusb
@@ -1 +1 @@
-Subproject commit 73896a3b71c525a3ee4cefa7e35ce3b3a93786ef
+Subproject commit ea8ecea59aa60a1028cce16b0f15bb33918b11af
diff --git a/ports/raspberrypi/sdk_config/pico/config_autogen.h b/ports/raspberrypi/sdk_config/pico/config_autogen.h
index a29ccb458a..ee99b1c609 100644
--- a/ports/raspberrypi/sdk_config/pico/config_autogen.h
+++ b/ports/raspberrypi/sdk_config/pico/config_autogen.h
@@ -18,6 +18,8 @@
 #define PICO_NO_HARDWARE (0)
 #define PICO_ON_DEVICE (1)
 #define PICO_PRINTF_ALWAYS_INCLUDED (1)
+#define PICO_RP2040_USB_DEVICE_ENUMERATION_FIX (1)
+#define PICO_RP2040_USB_DEVICE_UFRAME_FIX (1)
 #define PICO_STDIO_IGNORE_NESTED_STDOUT (0)
 #define PICO_USE_CRT_PRINTF (0)
 #define PICO_USE_OPTIMISTIC_SBRK (0)
diff --git a/ports/raspberrypi/supervisor/usb.c b/ports/raspberrypi/supervisor/usb.c
index d0e9b2e466..fb4f72134d 100644
--- a/ports/raspberrypi/supervisor/usb.c
+++ b/ports/raspberrypi/supervisor/usb.c
@@ -39,15 +39,8 @@ STATIC void _usb_irq_wrapper(void) {
 }
 
 void post_usb_init(void) {
-    irq_set_enabled(USBCTRL_IRQ, false);
-
-    irq_handler_t usb_handler = irq_get_exclusive_handler(USBCTRL_IRQ);
-    if (usb_handler) {
-        irq_remove_handler(USBCTRL_IRQ, usb_handler);
-    }
-    irq_set_exclusive_handler(USBCTRL_IRQ, _usb_irq_wrapper);
-
-    irq_set_enabled(USBCTRL_IRQ, true);
+    irq_add_shared_handler(USBCTRL_IRQ, _usb_irq_wrapper,
+        PICO_SHARED_IRQ_HANDLER_LOWEST_ORDER_PRIORITY);
 
     // There is a small window where the USB interrupt may be handled by the
     // pico-sdk instead of CircuitPython. If that is the case, then we'll have
diff --git a/ports/stm/Makefile b/ports/stm/Makefile
index 325b13b1bc..d6afeb5f29 100755
--- a/ports/stm/Makefile
+++ b/ports/stm/Makefile
@@ -215,7 +215,7 @@ ifneq ($(CIRCUITPY_AUDIOBUSIO_PDMIN),0)
 endif
 
 ifneq ($(CIRCUITPY_USB),0)
-SRC_C += lib/tinyusb/src/portable/st/synopsys/dcd_synopsys.c
+SRC_C += lib/tinyusb/src/portable/synopsys/dwc2/dcd_dwc2.c
 endif
 
 SRC_S = \
diff --git a/shared-module/usb/core/Device.c b/shared-module/usb/core/Device.c
index 81431d5d7a..706c94eec3 100644
--- a/shared-module/usb/core/Device.c
+++ b/shared-module/usb/core/Device.c
@@ -61,12 +61,9 @@ uint16_t common_hal_usb_core_device_get_idProduct(usb_core_device_obj_t *self) {
 }
 
 STATIC xfer_result_t _get_string_result;
-STATIC bool _transfer_done_cb(uint8_t daddr, tusb_control_request_t const *request, xfer_result_t result) {
-    // Store the result so we stop waiting for the transfer. We don't need the other data for now.
-    (void)daddr;
-    (void)request;
-    _get_string_result = result;
-    return true;
+STATIC void _transfer_done_cb(tuh_xfer_t *xfer) {
+    // Store the result so we stop waiting for the transfer.
+    _get_string_result = xfer->result;
 }
 
 STATIC void _wait_for_callback(void) {
@@ -89,7 +86,7 @@ STATIC mp_obj_t _get_string(const uint16_t *temp_buf) {
 mp_obj_t common_hal_usb_core_device_get_serial_number(usb_core_device_obj_t *self) {
     _get_string_result = 0xff;
     uint16_t temp_buf[127];
-    if (!tuh_descriptor_string_serial_get(self->device_number, 0, temp_buf, MP_ARRAY_SIZE(temp_buf), _transfer_done_cb)) {
+    if (!tuh_descriptor_get_serial_string(self->device_number, 0, temp_buf, MP_ARRAY_SIZE(temp_buf), _transfer_done_cb, 0)) {
         return mp_const_none;
     }
     _wait_for_callback();
@@ -99,7 +96,7 @@ mp_obj_t common_hal_usb_core_device_get_serial_number(usb_core_device_obj_t *sel
 mp_obj_t common_hal_usb_core_device_get_product(usb_core_device_obj_t *self) {
     _get_string_result = 0xff;
     uint16_t temp_buf[127];
-    if (!tuh_descriptor_string_product_get(self->device_number, 0, temp_buf, MP_ARRAY_SIZE(temp_buf), _transfer_done_cb)) {
+    if (!tuh_descriptor_get_product_string(self->device_number, 0, temp_buf, MP_ARRAY_SIZE(temp_buf), _transfer_done_cb, 0)) {
         return mp_const_none;
     }
     _wait_for_callback();
@@ -109,7 +106,7 @@ mp_obj_t common_hal_usb_core_device_get_product(usb_core_device_obj_t *self) {
 mp_obj_t common_hal_usb_core_device_get_manufacturer(usb_core_device_obj_t *self) {
     _get_string_result = 0xff;
     uint16_t temp_buf[127];
-    if (!tuh_descriptor_string_manufacturer_get(self->device_number, 0, temp_buf, MP_ARRAY_SIZE(temp_buf), _transfer_done_cb)) {
+    if (!tuh_descriptor_get_manufacturer_string(self->device_number, 0, temp_buf, MP_ARRAY_SIZE(temp_buf), _transfer_done_cb, 0)) {
         return mp_const_none;
     }
     _wait_for_callback();
@@ -125,11 +122,8 @@ mp_obj_t common_hal_usb_core_device_read(usb_core_device_obj_t *self, mp_int_t e
 }
 
 xfer_result_t control_result;
-STATIC bool _control_complete_cb(uint8_t dev_addr, tusb_control_request_t const *request, xfer_result_t result) {
-    (void)dev_addr;
-    (void)request;
-    control_result = result;
-    return true;
+STATIC void _control_complete_cb(tuh_xfer_t *xfer) {
+    control_result = xfer->result;
 }
 
 mp_int_t common_hal_usb_core_device_ctrl_transfer(usb_core_device_obj_t *self,
@@ -145,11 +139,17 @@ mp_int_t common_hal_usb_core_device_ctrl_transfer(usb_core_device_obj_t *self,
         .wIndex = wIndex,
         .wLength = len
     };
+    tuh_xfer_t xfer = {
+        .daddr = self->device_number,
+        .ep_addr = 0,
+        .setup = &request,
+        .buffer = buffer,
+        .complete_cb = _control_complete_cb,
+    };
+
     control_result = XFER_RESULT_STALLED;
-    bool result = tuh_control_xfer(self->device_number,
-        &request,
-        buffer,
-        _control_complete_cb);
+
+    bool result = tuh_control_xfer(&xfer);
     if (!result) {
         mp_raise_usb_core_USBError(NULL);
     }
diff --git a/supervisor/shared/usb/usb.c b/supervisor/shared/usb/usb.c
index fa85cddb83..5ac8454312 100644
--- a/supervisor/shared/usb/usb.c
+++ b/supervisor/shared/usb/usb.c
@@ -225,13 +225,17 @@ void usb_background_schedule(void) {
 }
 
 void usb_irq_handler(int instance) {
+    #if CFG_TUSB_MCU != OPT_MCU_RP2040
+    // For rp2040, IRQ handler is already installed and invoked automatically
     if (instance == CIRCUITPY_USB_DEVICE_INSTANCE) {
         tud_int_handler(instance);
-    } else if (instance == CIRCUITPY_USB_HOST_INSTANCE) {
-        #if CIRCUITPY_USB_HOST
-        tuh_int_handler(instance);
-        #endif
     }
+    #if CIRCUITPY_USB_HOST
+    else if (instance == CIRCUITPY_USB_HOST_INSTANCE) {
+        tuh_int_handler(instance);
+    }
+    #endif
+    #endif
 
     usb_background_schedule();
 }
diff --git a/supervisor/supervisor.mk b/supervisor/supervisor.mk
index 801025f41a..c461c5353f 100644
--- a/supervisor/supervisor.mk
+++ b/supervisor/supervisor.mk
@@ -163,7 +163,6 @@ ifeq ($(CIRCUITPY_USB),1)
     SRC_SUPERVISOR += \
       lib/tinyusb/src/host/hub.c \
       lib/tinyusb/src/host/usbh.c \
-      lib/tinyusb/src/host/usbh_control.c \
 
   endif
 endif